An experimental study was performed to investigate characteristics of an inverter driven water-to-water refrigeration system with a variation of compressor frequencies and expansion devices. The frequency of a compressor varied from 30Hz to 75Hz, and performance of the systems applying three different expansion devices such as capillary tube, thermostatic expansion valve(TXV), and electronic expansion valve(EEV) were measured. The load conditions were altered by varying the temperature of the secondary fluid entering condenser and evaporator with a constant flow rate. When the test conditions were deviated from the standard value(rated value), TXV and EEV showed better performance than capillary tube due to optimum control of mass flow rate and superheat. In the present study, it was observed that the variable area expansion device had better performance than constant area expansion device in an inverter refrigeration system due to active control of flow area with a change of compressor frequency and load conditions.