In this paper, we propose an algorithm to locate the corpus callosum automatically from midsagittal brain MR images using the statistical characteristics and shape information of the corpus callosum. In the proposed algorithm, we first extract regions satisfying the statistical characteristics of the corpus callosum and then find a region matching the shape information. In order to match the shape information, a new directed window region-growing algorithm is proposed instead of using conventional contour matching algorithms. Using the proposed algorithm, we adaptively relax the statistical requirement until we find a region matching the shape information. Experiments show promising results.