This study intends to find the empirical relationship between the environmental and organizational characteristics and the strategic use of information systems(SUIS). Sixty-five firms in Korea are surveyed and analyzed to understand the impact of these characteristics on SUIS. As environmental characteristics, we select dynamism, hostility, and heterogeneity. As organizational characteristics, we select centralization, formalization, and IS maturity. The result of correlation analysis shows that formalization and information systems maturity are correlated significantly with SUIS. The result of regression analysis reveals that formalization is a major determinant to influence on SUIS of organization. Also, additional analysis shows that service industry have higher extent of SUIS than manufacturing industry.