The previous studies regarding the stock returns have advocated that industry effects exist over entire industry. As the industry categories are more rigid, the demand for predicting the industry sectors is rapidly increasing. The advances in Artificial Intelligence and Neural Networks suggest the feasibility of a valuable computational model for stock returns prediction. We propose a sector-factor model for predicting the return on industry stock index using neural networks. As a substitute for the traditional models, neural network model may be more accurate and effective alternative when the dynamics between the underlying industry features are not well known or when the industry specific asset pricing equation cannot be solved analytically. To assess the potential value of neural network model, we simulate the resulting network and show that the proposed model can be used successfully for banks and general construction industry. For comparison, we estimate models using traditional statistical method of multiple regression. To illustrate the practical relevance of neural network model, we apply it to the predictions of two industry stock indexes from 1980 to 1995.