Identifying knowledge as the single most important asset ultimately defining organizational competitiveness, enterprises are trying to move towards knowledge-oriented practices. Such practices have given rise to learning and agile organization, This paper presents applied information technologies to realize the learning and agile organization, focusing on systems thinking. Firstly, in order to establish a framework for the systems thinking, an information systems development method based on process chain is proposed. Then, an agent-based microworld simulation approach is presented. The approaches provide visible and analytical information to knowledge workers so that they can have systems thinking capabilities eventually. Various microworlds on the top of the information system can be constructed with agents and simulated for possible business events. All decision makings are dynamic in nature. To let knowledge workers look ahead the possible outcomes of the whole relevant processes is the core capability of the approaches. Through watching, the knowledge workers would be able to acquire new insights or problem solving knowledge for the problem in hand.