Purpose: This study was to evaluate the effects of Aloe. Gelfoam. and Plaster of Paris on bone healing. Materials and Methods: Four experimental defects were created for placement of the three materials in the right femur of dogs. One defect served as an empty control site. The evaluation was performed at 1-. 6-. and 12-weeks by light microscopy and radiographs. Results: Radiographic and histologic examinations showed new bone formation in the presence of Aloe, Gelfoam. and Plaster of Paris and similar bone healing reactions. Conclusion: On the basis of these findings, it was concluded that Aloe, Gelfoam. and Plaster of Paris may be adequate agents for use in bone procurement.