This study has examined weight loss rates of Iyoceu, lyocell/cotton, cotton that were treated with cellulase under different concentration, time, temperature and pH. and compared physical properties changes of tensile strength, drape, moisture absorbency, shrinkage and dyeability. The notable results are summarized as follows: Lyocell was in need of pretreatment by NaOH in the side of weight loss, tensile strength and dyeability. Weight loss rates of cellulose fabrics by cellulase treatment were in the order of cotton > lyocell/cotton > lyocell at the same conditions. In case of lyocell and lyocell/cotton, weight loss rates showed up lower than cotton, while strength retention decreased, drape and strength flexibility were highly improved after cellulase treatment.