We propose a new method of asymptotic inference on the odds ratio (or cross-product ratio) in $2{ imes}2$ contingency table. Saddlepoint approximations to the conditional tail probability we used in this procedure. We assess the accuracy of the suggested method by comparing with the exact one. To obtain the exact values, we need very complicated calculations containing the cumulative probabilities of non-central hypergeometric distribution. The suggested method in this paper is very accurate even for small or moderate sample sizes as well as simple and easy to use. Example with a real data is also considered.