A nonlinear model for time-step analysis of bridges subjected to two orthogonal horizontal components of earthquake motions was developed. The focus of the study was on elastomeric isolators with or without lead cores. The hysteretic behavior of the isolators, the columns, abutments, and shear keys was taken into account. The nonlinear analysis showed that, contrary to linear theory prediction, the use of isolators does not necessarily increase the displacement of the superstructure. Furthermore, it was shown that properly designed isolators can reduce the ductility demand in RC bridge columns substantially.