The maximum work capacity at various shoulder angles was estimated in terms of joint moment through maximum voluntary contraction (MVC) measurement, and the result was compared to workload computed from 3-D static lifting model (3DSSPP) based upon national institute of safety and health (NIOSH) lifting guideline (1991). The electromyography (EMG) of anterior/posterior deltoid and trapezius muscle was also recorded to study the function of individual muscle during asymmetric shoulder lifting. Psychophysical workload was measured to observe the difference from MVC or biomechanical estimation. An apparatus was constructed for the study and twenty five trials including five flexion angles and five add/abduction angles were performed isometrically. Results indicated that MVC at 30 degree of flexion was the strongest whereas MVC at 120 degree was the weakest. In case of add/abduction, MVC decreased to 77 to 89 % during add/abduction compared to the MVC at neutral position. Regarding the normalized EMG value, a substantial increase was observed at 30 and 60 degree abduction. More importantly, the shoulder moment computed from maximum permissible limit (MPL) was greater than the moment at MVC condition during 30 degree adduction. Current result can be used as a reference information for a safe workplace design to prevent the shoulder from an excessive work load in industry.