This study was undertaken to identify the health-promoting behavior and to explore the relationship between health-promoting behavior, self-efficacy, self-esteem and climacteric symptoms among the middle-aged women. The subjects for this study were 101 women and data were obtained using a self-reported questionnaires. The Questionnaire was composed of a health promotion life styles profile, self-efficacy scale, self-esteem scale, and, climacteric symtoms check-list. Data was analyzed by the SAS program using ANOVA, Pearson correlation and stepwise multiple reggression. The results are summarized as follows : 1. The scores on the health-promoting behavior scale ranged from 46 to 114 with a mean score of 77.95(SD=12.99). 2. The scores on the health-promoting behavior of housewives was significantly higher than working women. 3. Stepwise multiple regression analysis showed that : 1) self-esteem was the main predictor and accounted for 21.75% of the total variance in health-promoting behavior 2) Self-esteem, climacteric symptoms and health-promoting behavior were contributors to quality of life. 4. In the relationship between variables, self-esteem was positively corelated with health-promoting behavior and negatively with climacteric symptoms. In conclusion, self-esteem, age and occupation were important variables in health-promoting behavior. The results of this study can be used for the management of health in middle aged women to Increase their quality of life of them.