Objectives : This experimental study was designed to investigate the effects of hormone changes in the rats with muscle atrophy in response to Strychnos nuxvonica L. Methods : 24 male rats with muscle atropht by hindlimb suspension method as experimental group and 6 normal male rats were used. Experimental group was administered Strychnos nuxvonica L. 3 times a day, 1mg/kg per one dosage P,O, After 2 to 4 weeks hormone changes in blood were analysed. Results and Conclusions : Norepinephrine and Epinephrine level in blood as they act neurotransmitting substances were significantly increased by administering Strychnos nuxvonica L.