The present study has been conducted to design the high efficiency centrifugal compressor for a R134a turbo-chiller. The centrifugal compressor consists of an impeller with splitters, two vaneless diffusers, a low-solidity vaned diffuser and a volute. A cycle analysis program for a turbo-chiller was developed to obtain compressor design parameters and requirements. We have designed the high efficiency centrifugal compressor by applying the repeated design procedure including a meanline design, a 3D geometry generation and fluid dynamic loading calculations.