In this paper, we design an adaptive neuro-fuzzy inference system(ANFIS) precompensator for load frequency control of 2-area power systems. While proportional integral derivative (PID) controllers are used in power systems, they may have some problems because of high nonlinearities of the power systems. So, a neuro-fuzzy-based precompensation scheme is incorporated with a convectional PID controller to obtain robustness to the nonlinearities. The proposed precompensation technique can be easily implemented by adding a precompensator to an existing PID controller. The applied neruo-fuzzy inference system precompensator uses a hybrid learning algorithm. This algorithm is to use both a gradient descent method to optimize the premise parameters and a least squares method to solve for the consequent parameters. Simulation results show that the proposed control technique is superior to a conventional Ziegler-Nichols PID controller in dynamic responses about load disturbances.