The present numerical study investigates heat transfer enhancement mechanism for suspensions of polystyrene particles in water. Numerical simulations were done for turbulent hydrodynamic fully developed flows in a circular duct with constant wall heat flux. The experimental result of microparticle suspensions show 25∼45% heat transfer enhancement over those of water. The present numerical results show the main parameter for the heat transfer enhancement of microparticle suspension in a circular duct is the change of velocity profile by the non-Newtonian fluid behavior.