Factors influencing the success or failure of information systems9IS) have been discussed in many literes. However, little thertical development or empirical research has examined effectiveness of information systems in health center. This study evaluates several model that contribute to IS success in bealth center. In this study, we propose a process model that exhibits several variables influence one after another. These can be classified into six different dimensions. These inclube system aspect, invidual effect. The system aspect is classified by system quality, information quality and service quality. On individual and organizational aspect, this study uses computer self-efficacy and support of top management. The results of this study are as follows: according to multiple regression analysis of user satisfaction, information quality and support of top management are statistically significant influence on user satisfaction. System quality and service quality are a partially significant influence on user satisfaction. Hypothesis 5, proposing that computer self-efficacy would relate positively to user satisfaction, ws not supported by the questionnaire results. Based on these results, information quality and support of top management are very important variables for IS success.