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Inhibitory Effects of Various Edible Plants and Flavonoids from the Leaves of Cedrela sinensis on Human Immunodeficiency Virus Type 1 Protease
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  • Inhibitory Effects of Various Edible Plants and Flavonoids from the Leaves of Cedrela sinensis on Human Immunodeficiency Virus Type 1 Protease
  • Inhibitory Effects of Various Edible Plants and Flavonoids from the Leaves of Cedrela sinensis on Human Immunodeficiency Virus Type 1 Protease
저자명
Park. Jong-Cheol,Hur. Jong-Moon,Park. Ju-Gwon,Kim. Hyun-Joo,Kang. Kyeong-Hee,Park. Myeong-Rak,Song. Sang-Ho
간행물명
Journal of food science and nutrition
권/호정보
2000년|5권 3호|pp.170-173 (4 pages)
발행정보
한국식품영양과학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The inhibitory effect of extracts from 15 edible plants on the protease of human immunodeficiency virus (HIV) type 1 was investigated. Protease activity was determined by incubating the extracts in a reaction mixture containing protease and substrate His-Lys-Ala-Arg-Val-Leu-(p-NO$_2$-Phe)-Glu-Ala-Nle-Ser-NH$_2$ to inhibit proteolytic cleavage. Of various plants tested, the leaves of Cedrela sinensis inhibited the HIV-1 protease by 42% at a concentration of 100$mu extrm{g}$/ml. A major flavonoid isolated from the leaves of C. sinensis, quercetin 3-O-$alpha$-L-rhamnoside showed inhibitory activity of 19% at a concentration of 100$mu$M.