The impact of apo E polymorphism on interindividual variation in plasma lipid profiles was studied in 215 well-defined Hyperlipidemia patients aged 55.12$pm$12.68 years. At least 45% of subjects had primary hyperlipidemia(HL) and the others had NIDDM(11%) hypertention(9%) and so on. Type IV was the most predominant HLP(58.33%) Type IIa, IIb, III and V were distributed by 17.59% 11.11%, 2.31% and 1.38% respectively. Type I was not found. 19 subjects(8.8%) was not assigned by HLP (non-HLP). Even though Total-C, LDL-C and VLDL-C in non-HLP were higher than those in HLP non-HLP has a low risk of CHD because of lower levels of TG an d AI=(TC-HDL)/HDL in non-HLP. Since Type V and III impact the clearence of TG-riched lipoproteins TG and VLDL-C levels were higher in V and III. Total-C and LDL-C were higher in Type II than those in the others. Apo A-I was not different between HLP comparing non -HLP otherwise apo B-100 was significantly higher in IIa, IIb. and V AI such as (TC-HDL)/HDL and LDL/HDL in Type V and II were higher than those in the others. As the relative frequencies of apo E phenotyping E3/3. E3/4, E3/2. E2/2, E2/4 and E4/4 were 0.782, 0.060, 0.972, 0.032, 0.019 and 0.095. Plasma LDL-C, VLDL-C, TG ratio of apo A-I /B-100 and (TC-HDL)/HDL were different among apo E isoforms. TG and VDLD-C in E2 allele were higher than that those in the others otherwise LDL-C in E4 allele was higher than that in the others respectively. LDL-C and VLDL-C were not different among six apo E phenotypes due to heterozygotes of apo E alleles has counterbalanced effects. Total -HDL-C, LDL+VLDL-C apo A-I apo B-100 ratio of LDL/HDL and Lp(a) wre not different among the apo E allels. Since high ratio of (TC-HDL)/HDL and low ratio of LDL/HDL in apo E2 was happened AI should be carefully concerned to elucidate the CHD risk