In the design of epicyclic gearing, the analysis of interference and mechanical efficiency is an important index. As an applied way, epicyclic gearing can be used for planetary gear drive and differential gear unit. In case that one of its components is fixed with intend, it is called planetary gear drive. On the contrary, in case that no component is fixed, it is called differential gear unit. In this paper, various design constraints and interferences are defined for 2K-H I type epicyclic gearing which is a basic arrangement of diverse epicyclic gearings. And various interferences are analyzed, and mechanical efficiency is calculated in case that 2K-H I epicyclic gearing is used for a differential gear unit as the change of gear ratio, cutter pressure angle, addendum modification coefficient. As that results, trend of mechanical efficiency is investigated in the ranges of addendum modification coefficients which would not lead to interferences, and the optimal range of addendum modification coefficient which can generate the maximum mechanical efficiency are presented. In order to prove results of theoretical efficiency analysis, experimental studies are performed.