The equations prescribed in Ω⊂R(sup)n are called loaded, if they contain some operations of the traces of desired solution on manifolds (of dimension which is strongly less than n) from closure Ω. These equations result from approximations of nonlinear equations by linear ones, in the problems of optimal control when the control when the control actions depends on a part of independent variables, in investigations of the inverse problems and so on. In present work we study the nonlocal boundary value problems for first-order loaded differential operator equations. Criterion of unique solvability is established. We illustrate the obtained results by examples.