R-410A, R-407C, and four refrigerant mixtures composed of R-32, R-l34a, R-l43a, R-l52a, R-600(butane), and R-600a(isobutane) were tested in an attempt to replace R-22 used in most of the residential air conditioners. The performance evaluation was carried out in a psychrometric calorimeter test facility using a residential spilt type air conditioner under the KS rating conditions. Except for the lubricant and hand-operated expansion valve, the other parts of the air conditioner were the same with the commercial system. Performance characteristics were measured; COP, capacity, compressor power, and VCR. R-410A was shown to have 5.5% higher COP and 3.5% lower capacity than R-22. R-32/134a/600a (42.8/ 46.0/11.2 wt%) mixture have the best performance among the four refrigerant mixtures composed of hydrofluorocarbon and hydrocarbon. This inixture have 3.0% lower COP and 1.6% lower capacity than R-22.