Thermal comfort plays an important role in modern office buildings. Four major factors affecting thermal comfort are air temperature, velocity, humidity and radiation temperature. Distribution of these thermal factors in indoor space depends largely on the air flow which is related to the method of supplying and extracting air. In this study, an experimental analysis on indoor thermal comfort is conducted to study the difference between a ceiling supply cooling system and a floor supply one. The two cooling systems are applied to an office space during summer season and the distributions of temperature, velocity, radiation temperature and PMV are measured. Results show that the floor supply cooling system is superior in terms of thermal comfort and energy saving. Studies need to be done, however, to reduce the vertical temperature difference of a floor supply air conditioning system.