This paper deals with the development of fault tolerant control for a nonlinear boiler system with noise and disturbance. The MCMBPC(Multivariable Constrained Model Based Predictive Control) is adopted for the control of the specific boiler turbin model. The fault detection and diagnosis are accomplished with the Kalman filter and two bias estimators. Once a fault is detected, two Bias estimators are driven to estimate the fault and to discriminate Process fault and sensor fault. In this paper, a fault tolerant control scheme combining MCMBPC with a fault compensation method based on the bias estimator is proposed. The proposed scheme has been applied to the nonlinear boiler system and shown a satisfactory performance through some simulations.