We propose a new method to deal with the optimal gain self-tuning of the PID controller which is used to industrial process control in various fields. First of all, in this method, first order delay system which was modeled from the unit step response of the system is Pade-approximated, then initial values are determined by the Ziegler-Nickels method. Finally, we can find the parameters of Pm controller so as to maximize the fuzzy inferencl function which includes the maximum overshoot, damping ratio, rising time and settling time. The proposed method also shows good adaptability for variations in characteristics and dead time of the system.