Objectives : This study was undertaken to examine the clinical effect of ECM.E, made of hyaluronic acid, on dysmenorrhea. Methods : This study involved 44 women with dysmenorrhea. During the three-month study, 3T was administered to them twice a day and they were examined on their menstrual state three times. The degree of pain was measured by VAS. Conclusions : The followings are the conclusions from the study. 1. ECM.E yielded a significant effect on making the menstrual color healthy and reducing the amount of the menstrual clots. 2. ECM.E yielded a significant effect on reducing PMS, especially the mammary pain before menstruation. 3. ECM.E yielded a significant effect on reducing dysmenorrhea, especially the pain of lower abdomen, fatigue and abnormal excrements during menstruation.