The present study is mainly motivated to investigate the vaporization, auto-ignition and combustion processes in the high-pressure engine conditions. The high-pressure vaporization model is developed to realistically simulate the spray dynamics and vaporization characteristics in high-pressure and high-temperature environment. The interaction between chemistry and turbulence is treated by employing the Representative Interactive Flamelet (RIF) Model. The detailed chemistry of 114 elementary steps and 44 chemical species is adopted for the n-heptane/air reaction. In order to account for the spatial inhomogeneity of the scalar dissipation rate, the multiple RIFs are introduced. Numerical results indicate that the RIF approach together with the high-pressure vaporization model successfully predicts the ignition delay time and location as well as the essential features of a spray ignition and combustion processes.