Purpose: To determine whether the significant relationship exists between radiographic appearance, whether it is unilocular or multilocular, and its corresponding clinical and histologic features by examining the odontogenic keratocyst clinically, radiologically and histologically. Materials and Methods: This study was conducted on 48 cases of odontogenic keratocyst from the files of Dental Hospital, Yonsei University for the years 1982 through 1995. Results and Conclusions : The mean age of patients was 30.5 years in the unilocular group and 35.5 years in the multilocular group. The male to female ratio was 1 : 1.06 in the unilocular group and 1 : 1.75 in the multilocular group. The chief complaint was swelling in both groups(unilocular 35.1 %, multilocular 54.5%). In the occurrence site, the border of the lesion, the displacement and external root resorption of the adjacent teeth, there were no statistically significant difference between the unilocular group and multilocular group, but in the border type, there was statistically significant difference (x²-test, p<0.05)wo recurred cases were observed among 11 cases of odontogenic keratocyst. One was unilocular case and the other was multilocular case.