In this study, a failure mode analysis of CNC machining center is described. First, the system is classified through subsystems into components using part lists and drawings. The component failure rate and failure mode analysis are performed to identify the weak components of a machining center with reliability database. The failure probabilistic function of mechanical part is analyzed by Weibull distribution. The Kolmogorov-Smirnov test is also used to verify the goodness of fit.