Flow boiling heat transfer coefficients(HTCs) of R22, R134a, R407C, and R410A were measured experimentally for a horizontal plain and a microfin tube. Experimental apparatus was composed of 3 main parts: a refrigerant loop, a water loop and a water-glycol loop. The test section in th refrigerant loop was made of a copper tube of 9.52 mm outer diameter and 1 m length for both tubes. The refrigerant was heated by passing hot water through an annulus surrounding the test section. Tests were performed at a fixed refrigerant saturation temperature of $5^{circ}C$ with mass fluxes of 100~300 kg/<TEx>$m^2$</TEX>s. Test results showed that at similar mass flux the flow boiling HTCs of R134a were similar to those of R22 for both plain and microfin tube. HTCs of R407C were similar to those of R22 for a plain tube but lower than those of R2 by 25~48% for a microfin tube. And HTCs of R410A were higher than those of R2 by 20~63% for a plain tube and were similar to those of R22 for a microfin tube. In general, HTCs of a microfin tube were 1.8~5.7 times higher than those of a plain tube.