The mathematical model of a air-conditioning system is generally very complex and difficult to apply to controller design. In this paper, simple models applicable to the controller design are obtained by modeling the air-conditioning system by single-input single-output between compressor speed and indoor temperature, and by multi-input single-output between compressor speed, indoor fan speed and indoor temperature. Using these empirical models, model predictive control(MPC) technique was implemented for indoor temperature control of the air-conditioning system. It has been shown from various experiments that the indoor temperature control based on the MPC scheme yields reasonably good tracking performance with smooth changes in plant inputs. this multi-input multi-output MPC approach can be extended to multi air- conditioning systems where the conventional PID control scheme is very difficult to apply.