In this paper an ANFIS(Adativo Neuro-Fuzzy Inference System)- based fault detection and diagnosis for a closed loop control system is proposed. The proposed diagnostic system contains two ANFIS. One is run as a parallel model within the model in closed loop control(MCL) and the other is run as a series-parallel model within the process in closed loop(PCL) for the generation of relevant symptoms for fault diagnosis. These symptoms are further processed by another classification logic with simple rules and neural network for process and controller fault diagnosis. Experimental results for a DC shunt motor control system illustrate the effectiveness of the proposed diagnostic scheme.