This study is intended to understand an implication and significant of anti-design and Italian radical fashion. Anti-design and radicalism is the main stream or origin and essence of post-modernism which hs been swaying our society at large through modern culture, economy, art, fashion etc, from the latter part of 1960s. In this paper, the author classified the italian radical fashion with the Archizoom, the Alchymia, the memphis fashion. In post-modernism fashion, radical fashion design of the Archizoom, Alchymia and Memphis group is in part a menifesto and in part a noncanonical history of the most progressive and heretical experiments of the world of fashion. Anti-designers of Italy call for a theory an practive in which the old methods and instruments and the old commendments of modernism are banished. They looked on fashion as material culture, a creative field with its own independent foundation and endowed with its own strong artistic intuition. IF radical design is dead, the energy it has stirred up is still alive nd kicking. One of the most progressive and well-informed culture milieus in Milian, seved as a point of reference for the vanguard of fashion.