In this seismic analyses of structures, it is well recognized that the effects of soil-structure interaction can not be ignored and seismic responses of a structure taking into account the stiffnesses of a foundation-soil system show the significant difference from those with a rigid base. However, current seismic analyses of apartment building structures were carried out with the rigid base ignoring the characteristics of the foundation and the properties of the underlying soil. In this study, seismic analyses of wall-slob type apartment buildings which have a particular structural type were carried out taking into account the soft soil layer comparing seismic response spectra of a flexible base with those of a rigid base and UBC-97. Low-rise or middle height wall-slab type apartment buildings built on the deep soft soil layer showed a rigid body motion with the reduced seismic responses due to the base isolation effect, indicating that it is considerably safe but uneconomical to utilize the design spectra of UB-97 for the seismic design of wall-slab type apartment buildings due to conservative design.