The purpose of this paper is to determine the effect of the autoclave inner pressure rate, heat-up rate, tool round angle, Thickness of core, height of joggle on defects, and to minimize the defects of aircraft sandwich structure reinforced with honeycomb core occurred in autoclave processing. The results showed that the geometry of aircraft sandwich structure and tool such as tool round angle, thickness of core, height of joggle, and the autoclave cure conditions such as inner pressure rate, heat up rate strongly affected the core movement, core wrinkle, bridge phenomenon of prepreg and depression of core that occurred in autoclave processing.