To investigate the feasibility of developing a new tenoxicam plaster, the effects of vehicles and penetration enhancers on the in vitro permeation of tenoxicam from a pressure-sensititre adhesive (PSA) matrices across the dorsal hairless mouse skin were studied. Vehicles employed in this study were propylene glycol (PC)-oleyl alcohol (OAI), PG-oleic acid (OA), and diethylene glycol monoethyl ether (DCMI)-propylene glycol monolaurate (PCML) cosolvents with/without fatty acids. In this studys amines such as triethanolamine (TEA) and tromethamine (TM) were additionally used as a solubilized. Among PSAs used, $Duro-Tak^{circledR}$87-2510 showed much higher release rate than either $Duro-Tak^{circledR}$ 87-2100 or $Duro-Tak^{circledR}$87-2196. The relatively high flux rate was obtained with the formulation of DCMI-PCML (40:60, v/v) with 3% OA and 5% TM, and the flux increased as a function of the dose;the initial flux up to 12 h was $4.98{pm}1.38{;}{mu extrm{g}}/{ extrm{cm}^2}/h$ at the tenoxicam dose of $50{;} mg/70{;}{ extrm{cm}^2}$. This flux was much higher than that of a commercial piroxicam patch ($Trast^{circledR}$) ($1.24{pm}0.73{;}{mu extrm{g}}/$ extrm{cm}^2/hr$) with almost only one-third that of the commercial patch. Therefore, these observations indicated that these composition of tenoxicam plaster may be practically applicable.