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A Study on the DNA Polymorphisms at $eta$fibrinogen Loci and Plasma Fibrinogen Concentration
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  • A Study on the DNA Polymorphisms at $eta$fibrinogen Loci and Plasma Fibrinogen Concentration
  • A Study on the DNA Polymorphisms at $eta$fibrinogen Loci and Plasma Fibrinogen Concentration
저자명
Lee. Mi-Hwa,Ohrr. Hee-Choul,Song. Kyung-Soon
간행물명
The Journal of biomedical laboratory sciences
권/호정보
2001년|7권 3호|pp.151-159 (9 pages)
발행정보
대한의생명과학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Many prospective studies have confirmed the predictive value of plasma fibrinogen levels for vascular diseases, including ischemic heart disease. Several polymorphisms of the $eta$fibrinogen gene have been investigated in relation to plasma fibrinogen levels. The blood samples for DNA were collected from 109 healthy Koreans who have no relationship by blood (67 males and 42 females) in due consideration of some other factors such as gender, age, and smoking status. Four polymorphisms of the $eta$fibrinogen gene that consist of HaeIII, AluI, MaII and BcII restriction fragment length polymorphisms (RFLPs) were investigated to examine the associations between RFLPs and plasma fibrinogen levels. In conclusion, the significant associations between HaeIII, AluI, MnII RFLPs(H$_1$H$_2$, M$_1$M$_2$, $A_1$A$_2$) and the concentration of plasma fibrinogen were shown by the smokers as well as by the old people more than 50, whereas the association between BcII and plasma fibrinogen were shown no connection with the status of age and smoking. The concentration of plasma fibrinogen was significantly shown higher by the old people ($geqq$50) by the younger people ($leqq$49) in male and also higher by the smokers than by the nonsmokers.