In this paper, we synthesized vowel /ae/ with voice synthesis program of Dr. Speech Science, and we also synthesized pathologic vowel /ae/ by some parameters such as high frequency gain (HFG), low frequency gain(LFG), pitch flutter(PF) which represents jitter value and flutter of amplitude(FA) which represents shimmer value, and grade ranked as mild, moderate and severe respectively. And then we analysed all pathologic voice by analysis program of Dr. Speech Science. We expect that this synthesized pathologic voices are useful for understanding the parameter such as noise, jitter and shimmer and feedback effect to patient with voice disorder.