Six Sigma was introduced into Korea in 1997, and it is regarded as a fascinating management strategy in many Korean companies. First of all, the reasons why Six Sigma is fascinating are given and a smart way to introduce Six Sigma is illustrated. Seven step procedures to introduce Six Sigma are explained. Next, the differences of problem-solving processes for project team activities for R&D, manufacturing, and service areas are compared. Third, a typical process for R&D Six Sigma is proposed, and major activities and scientific methods at each process step are suggested. Fourth, some differences between Six Sigma project team and quality circle team are presented. Finally, a Six Sigma model for e-business is proposed and briefly explained.