Two-level factorial designs are popular in industry due to their simplicity, efficiency, graphical interpretation, and flexibility in sequential experimentation. However, experimenters are often frustrated when they have factors with more than two levels. There have been some works on design of experiments with two- and four-level factors, which mostly deal with qualitative four-level factors. This paper discusses differences between qualitative and quantitative four-level factors. Optimal designs are provided for some designs with four-level quantitative and two-level factors.