In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.