This paper describes to extend the MLFMA(Multi-Level Fast Multipole Algorithm) for three-dimensional capacitance computation in the case of conductors embedded in an arbitrary dielectric medium. The triangular meshes are used and refined in the area which has heavy charge density. This technique is applied to the capacitance extraction of three-dimensional structures with multiple dielectrics. The results show good convergence with the comparable accuracy, and this adaptive technique coupled with MLFMA is useful to reduce computing time and the number of elements with least additional computational efforts in large three dimensional problems.