An experimental and analytical study was made on the heat transfer characteristics of one small (150 W), two medium (60 and 1,500 W, respectively) and two large (7,500and 100,000 W) two-phase loop thermosyphons (TLT), and the results from the experiments were used to see if a computer simulation code alone for such TLT heat transfer systems would give any meaningful quantitative results without being accompanied with some benchmark experimental verification. Two simulation methods were used for the analysis of the systems, i.e., the lumped and the sectorial thermal resistance methods. The study clearly shows that the computer simulation for the three TLTs can predict the most cases of the affecting parameters involved, provided that correct empirical correlations are used. To do so, however, the interior temperature distribution had to be verified by experiment.