The physical responses and subjective sensations of different cleanroom garments were compared in order to discover which cleanroom garment design could minimize pollution of the working environment by dust from the worker, maintain a pleasant microclimate and provide effective thermoregulation. <Garment Designs> A. Coverall with non-detachable hood, kimono sleeves (front), raglan sleeves (back), raschell net on the bodice B. Coverall with detachable hood, kimono sleeves (front), raglan sleeves (back), raschell net on the bodice C. Separate top with non-detachable hood, kimono sleeves (front), raglan sleeves (back), raschell net on the bodice D. Coverall with non-detachable hood, set-in sleeves, raschell net on the bodice E. Coverall with non-detachable hood, raglan sleeves (back), l00% cotton inner wear (upper body) The results of the experiment were as follows. Because the hood covered the shoulder and the chest areas, the chests temperature of the worker wearing garment E was quite higher than those wearing other garment designs. For fabric that has been coated in order to prevent dust, layered designs should be avoided in order to prevent skin temperature from rising. Compared with layers of underwear, it would be more effective to attach a see-through raschell net which clings to the body. Thermal sensations were also highest in garment E, reinforcing the finding that layered designs should be avoided. Through the experiment, it was found that a new material coverall with a non-detachable hood was effective in minimizing dust, suppressing skin temperature increases, maintaining a superior microclimate and providing pleasant subjective sensations.