Anisotropy of stiffness, from extremely small strains to post-failure strains, of isotropically consolidated air-pluviated sands in plane strain compression was studied by using the newly developed instrumentation fur small strain measurements, Seven types of sand of world-wide origins were tested, which have been extensively used for research purposes. Stress-strain relationships for a wide range of strain from about 0.0001% to the peak were obtained by measuring axial and lateral strains locally free from the effects of bedding and membrane penetration errors at the specimen boundaries. The result showed that the relationship between the principal stress ratio and the principal strain increment ratio was constant, being rarely affected by the over-consolidation ratio and the confining pressure. Although in the small strain the anisotropy hardly affected the relationship between the principal stress ratio and the principal strain increment ratio, the K value around the peak varied according to the $delta$ value. In general, Rowe`s stress-dilatancy equation works fairly well from the small strain to the peak.