Computer simulation is essential to design the suspension elements of railway vehicle. By computer simulation, engineers can assess the feasibility of given design variables and chance them to get a bettor design. Even though commercial simulation codes are used, the computational time and cost remains non-trivial. Therefore, malty researchers have used a mesa model made by sampling data through simulation. In this paper, four mesa-models for each index group such as ride comfort, derailment Quotient, unloading radio and stability index, are constructed by use of neural network. After these meta models are constructed, multi-objective optimization are achieved by using the differential evolution. This paper shows that the optimization of design variables using the neural network model is very efficient to solve the complex optimization Problem.