A new method to govern the navigation of a mobile robot using hand gesture recognition is proposed based on the following two procedures. One is to achieve vision information by using a 2-DOF camera as a communicating medium between a man and a mobile robot and the other is to analyze and to control the mobile robot according to the recognized hand gesture commands. In the previous researches, mobile robots are passively to move through landmarks, beacons, etc. In this paper, to incorporate various changes of situation, a new control system that manages the dynamical navigation of mobile robot is proposed. Moreover, without any generally used expensive equipments or complex algorithms for hand gesture recognition, a reliable hand gesture recognition system is efficiently implemented to convey the human commands to the mobile robot with a few constraints.