The proposed immune algorithm has an uncomplicated structure and memory-cell mechanism as the optimization algorithm which imitates the principle of humoral immune response. We use the proposed algorithm to solve parameter optimization problems. Up to now, the applications of immune algorithm have been optimization problems with non-varying system parameters. Therefore the usefulness of memory-cell mechanism in immune algorithm is without. This paper proposes the immune algorithm using a memory-cell mechanism which can be the application of system with nonlinear varying parameters. To verified performance of the proposed immune algorithm, the speed control of nonlinear DC motor are performed. The results of Computer simulations represent that the proposed immune algorithm shows a fast convergence speed and a good control performances under the varying system parameters.