In this study, structural optimum design was applied to the girder of magnet over head crane. The optimization was carried out using ANSYS Code for the deadweight of girder, especially focused on the thickness of its upper, lower, side and reinforced plates. The weight could be reduced up to around 15% with constraints of its deformation, stress, natural frequency and buckling strength. The structural safety was also verified by the buckling analysis of its panel structure. It might be thought to be very useful to design the conventional structures for the weight save through the structural optimization. Also this paper grasped the sensitivity influenced the design variables upon the objective function and the state variables.