A reliability analysis is performed to investigate the influence of the uncertainty from few in-situ samples and inherent heterogeneity of the ground on the probability of failure for a rock cut slope. The results are compared with those of deterministic slope stability analysis. The random variables used are unit weight of the rock, the angle of potential slope of failure, and cohesion and internal friction angle of joints. It was found that the rock slope in which the factor of safety satisfied the minimum safety factor in the deterministic analysis has high probability of failure in the reliability analysis when the weak geological strata are involved in the cut slope. The probability of failure of rock slope is most sensitive to the mean and standard deviation of cohesion in rock joint among the random soil parameters included in the reliability analysis. Sensitivities of the mean values are larger than those of standard deviations, which means that accurate estimation of the mean for the in-situ geotechnical properties is important.