This paper presents fault detection scheme of Brushless DC(BLDC) motor drive system by estimating BLDC motor resistance using motor input and output data which is transmitted from data acquisition board to host computer over serial communication channel. Since communication time delay has a serious effect on performance, we use periodic and fixed communication protocol. Hence, the delay time is priory known. Simplified BLDC motor model and recursive least square algorithm is used for estimating motor resistance. By experiment result, we confirm the proposed scheme.